This expert guide details a multi-faceted approach to joint and bone health, covering evidence-based medicines, natural supplements, and lifestyle interventions. It explains the science behind cartilage deterioration and bone density loss, highlighting key supplements like Glucosamine, Chondroitin, and Vitamin D3. The article also discusses prescription options—such as NSAIDs for pain and Bisphosphonates for osteoporosis—while emphasizing the critical roles of weight-bearing exercise and an anti-inflammatory diet in maintaining long-term mobility.