The title refers to understanding, preventing, and treating common wrist injuries in boxing. These injuries, such as sprains, fractures, and tendonitis, are often caused by improper punching technique, a lack of conditioning, or inadequate use of hand wraps and gloves. The content would offer solutions to "knock out" or eliminate the pain, including learning correct form, strengthening wrist and forearm muscles, using proper protective gear, and following R.I.C.E. (Rest, Ice, Compression, Elevation) for treatment.